Models for Taxol Biosynthesis: SeO2 Oxidation of Taxadiene |
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| Authors: | Qiulong Huang James D Pennington Howard J Williams |
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| Institution: | 1. Department of Chemistry , Texas A &2. M University , College Station, Texas, USA |
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| Abstract: | Together with the expected mono‐oxidized taxa‐4(20),11(12)‐diene‐5‐ol (1) and taxa‐4(5),11,20‐diene‐20‐ol (2), a new taxane skeleton, 3,12‐cyclotaxane (3), was obtained from chemical oxidation of taxadiene by selenium dioxide/t‐butylhydroperoxide. |
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| Keywords: | Taxol biosynthesis taxadiene oxidation |
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