Regioselective Opening of Chalcone Epoxides with Nitrogen Heterocycles Using Indium(III) Chloride as an Efficient Catalyst

Indium(III) chloride catalyzes regioselective ring opening of chalcone epoxides with nitrogen heterocycles such as indole, 2-methyl indole, and pyrrole under mild conditions at room temperature to afford 1,3-diaryl-2-hydroxy-3-(1H-3-indolyl/2-pyrrolyl)propan-1-ones in good yields (60–88%) within 20–50 min.

Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.