One-Pot Synthesis of Salicylanilides by Direct Amide Bond Formation from Salicyclic Acid Under Microwave Irradiation |
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| Authors: | Cheng-Rong Lu Ying-Peng Jiang Hao Ding Sheng Yang |
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| Affiliation: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Dushu Lake Campus, Soochow University , Suzhou , Jiangsu , China |
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| Abstract: | A highly efficient protocol for the preparation of aromatic amides is described by the direct reactions between salicyclic acid and aromatic amines in the presence of phosphorous trichloride under microwave irradiation. The method has several advantages over the conventional methods, including operational simplicity, good yield, and reduced reaction time.  Additional information ACKNOWLEDGMENT We are grateful to the Junzheng Scholar Project of Soochow University for financial support. |
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| Keywords: | Microwave irradiation salicylanilide synthesis |
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