Synthesis of New Quinoxaline Derivatives |
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Authors: | A Makhloufi M Merbah D Benachour |
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Institution: | Faculté des sciences de l'ingénieur, Département de génie des procédés , Laboratoire des matériaux polymériques multiphasiques, Université Ferhat Abbas , Sétif , Algeria |
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Abstract: | New quinoxaline derivatives were prepared by the reaction of 2-hydroxyquinoxaline 1 and alkyl or alkylaminoalkyl halides in dimethylformamide using potassium carbonate as a base. The hydroxyl group was readily converted into a thiol function by treatment with phosphorus pentasulfide and/or Lawesson's reagent in pyridine, and the subsequent alkylation of the thiol group was carried out under phase-transfer catalyst conditions. Chlorination of 1 was carried out with phosphorus oxychloride. Branching of alkylamino side chains to the 2-OH, 2-SH, and 2-Cl quinoxalines resulted in the synthesis of several compounds. Synthesis and alkylation of 2-hydroxy 7-nitroquinoxaline are also reported. ![id=](/na101/home/literatum/publisher/tandf/journals/content/lsyc20/2011/lsyc20.v041.i23/00397911.2010.519091/production/images/medium/lsyc_a_519091_o_uf0001.gif) |
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Keywords: | Alkylation aminoalkylation chlorination quinoxalines thiation |
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