Synthesis of Some Novel N-Substituted Phthalazinone and Pyridopyridazinone Derivatives |
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| Authors: | Zbigniew Malinowski Dariusz Sroczyński Aleksandra K. Szcześniak |
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| Affiliation: | 1. Faculty of Chemistry, Department of Organic Chemistry, University of ?ód?, ?ód?, Polandzbigmal@uni.lodz.pl;3. Faculty of Chemistry, Department of Inorganic and Analytical Chemistry, University of ?ód?, ?ód?, Poland;4. Faculty of Chemistry, Department of Organic Chemistry, University of ?ód?, ?ód?, Poland |
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| Abstract: | Phthalazinone and pyridopyridazinone derivatives 3, 5, and 9 were prepared via reaction ofappropriate lactams 2 and 8 with 2-bromoethylphthalimide, N-tosylaziridine, and N,O-ditosyl derivatives of N-methylethanolamine in a two-step process in the presence of MeONa/MeOH or NaH/dimethylformamide (DMF). Starting compounds 2 and 8 were obtained by reaction of hydrazine hydrate with isoindolinones 1 or azaisoindolinones 6. Selected N-(2-phthalimidoethyl)-phthalazinones were converted into corresponding 2-[2-(methylamino) ethyl]- derivatives in satisfactory yields by treatment with hydrazine. |
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| Keywords: | Alkylation amines phthalazinone pyridopyridazinone |
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