Synthesis of Galactosylhydroxylysine and its Analogs |
| |
| Authors: | Maciej Adamczyk Rajarathnam E. Reddy Sushil D. Rege |
| |
| Affiliation: | Department of Chemistry (9NM, AP20) , Diagnostics Division, Abbott Laboratories , 100 Abbott Park Road, Abbott Park, IL, 60064--6016, USA |
| |
| Abstract: | Synthesis of (--)-galactosylhydroxylysine (GHL, I), and its analogs (+)-2 and (+)-3, which are essential for development of assays for osteoporosis, is described starting from (2S,5R)-(+)-hydroxylysine (4). |
| |
| Keywords: | Phenylisothiocyanate Cyanoketene S,N‐acetals Pyrazoles |
|
|
