A silver nanoparticles-catalyzed efficient three-component synthesis of polysubstituted 4H-chromenylphosphonates and their antioxidant activity |
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| Authors: | Sara Mahdjoub Muhammet Yildirim Sihem Lakehal Houssem Boulebd Abdelmadjid Debache |
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| Affiliation: | 1. Laboratory of Synthesis of Molecules with Biological Interest, Frères Mentouri-Constantine University, Constantine, Algeria;2. Department of Chemistry, Faculty of Sciences and Arts, Abant Izzet Baysal University, Bolu, Turkey;3. Higher National School of Biotechnology, Constantine, Algeria;4. Laboratory of Natural Products of Plant Origin and Organic Synthesis, Frères Mentouri-Constantine University, Constantine, Algeria |
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| Abstract: | AbstractA simple and efficient protocol for one-pot three-component synthesis of structurally diverse dialkyl 2-amino-3-cyano-4H-chromen-4-ylphosphonates from the condensation of salicylaldehydes, malononitrile, and trialkyl phosphite using silver nanoparticles as catalyst in ethanol at reflux has been developed. Selected new compounds were evaluated for their antioxidant activity by free radical screening using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Among the compounds employed, 5a, 5?b, and 5?h showed promising DPPH radical scavenging activities compared to the experimental standards at low concentration (100?µg/mL) after 24?h incubation. |
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| Keywords: | Antioxidant activity dialkyl 2-amino-3-cyano-4H-chromen-4-ylphosphonates multicomponent reaction nanocatalyst silver nanoparticles |
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