Facile and Versatile Room-Temperature Synthesis of N,N-Disubstituted Cyanoacetamides from Malonic Ester Chloride |
| |
| Authors: | Andrzej Manikowski Zofia Kolarska |
| |
| Institution: | 1. PLIVA Kraków Pharmaceutical Company , Kraków, Poland andrzej.manikowski@yahoo.com;3. PLIVA Kraków Pharmaceutical Company , Kraków, Poland |
| |
| Abstract: | A general method for the synthesis of various N,N-disubstituted cyanoacetamides from readily available methyl malonyl chloride and secondary amines, including sterically demanding aliphatic and aromatic amines, is described. |
| |
| Keywords: | Cyanoacetamides dehydration malonamides nitriles |
|
|
