A Facile Synthesis of Pyrimidone Derivatives and Single-Crystal Characterization of Pymetrozine |
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| Authors: | Baozhu Wang Shaoyong Ke Babu Kishore Xiaoyong Xu Zhuyan Zou |
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| Institution: | Shanghai Key Laboratory of Chemical Biology, School of Pharmacy , East China University of Science and Technology , Shanghai , China |
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| Abstract: | A facile and efficient synthetic methodology for the preparation of aza-pyrimidone and beno-pyrimidone derivatives is described, in which the triazinone ring and dihydroquinazolin-2(1H)-one was convenient constructed. The structures of all the newly synthesized compounds were characterized by mass, 1H NMR, and infrared spectroscopy. In additional, the crystal of pymetrozine was obtained to find useful information such as configuration and molecular action mechanisms. |
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| Keywords: | Crystal pymetrozine pyrimidone synthesis |
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