Green Method for the Synthesis of Benzo[f]pyrimido[4,5-b]quinoline Derivatives Catalyzed by Iodine in Aqueous Media |
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| Authors: | Xiang-Shan Wang Qing Li Jian-Rong Wu Mei-Mei Zhang |
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| Institution: | 1. School of Chemistry and Chemical Engineering , Xuzhou Normal University , Xuzhou, Jiangsu, China;2. Key Laboratory of Biotechnology for Medical Plant , Xuzhou Normal University , Xuzhou, Jiangsu, China xswang1974@yahoo.com;4. School of Chemistry and Chemical Engineering , Xuzhou Normal University , Xuzhou, Jiangsu, China;5. Key Laboratory of Biotechnology for Medical Plant , Xuzhou Normal University , Xuzhou, Jiangsu, China |
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| Abstract: | A convenient one-pot synthesis of benzof]pyrimido4,5-b]quinoline derivatives is described via three-component reaction of benzaldehydes, naphthalen-2-amine, and barbituric acid at room temperature in aqueous media catalyzed by iodine. Compared with other methods, this three-component reaction used a green solvent, gave good yields, and was operationally simple. |
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| Keywords: | Aqueous media benzo[f]pyrimido[4 5-b]quinoline iodine three-component reaction |
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