Facile Stereoselective Synthesis of (E)-1-Arylseleno-Substituted 1,3-Enynes and Their Applications in Synthesis of (E)-Enediynes |
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| Authors: | Xiaoniu Fang Minhua Jiang Ronghua Hu |
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| Institution: | 1. Department of Chemistry , Jiangxi Normal University , Nanchang, China;2. Department of Chemistry , Jinggangshan University , Jian, China;3. Department of Chemistry , Jiangxi Normal University , Nanchang, China;4. Department of Chemistry , Jinggangshan University , Jian, China |
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| Abstract: | (E)-1-Iodo-2-arylselenoethylenes 1 underwent the Sonogashira coupling reactions with terminal alkynes 2 to afford (E)-1-arylseleno-substituted 1,3-enynes 3 in high yields. (E)-1-Arylseleno-substituted 1,3-enynes 3 were coupled with alkynylmagnesium bromides 4 in the presence of a catalytic amount of NiCl2(PPh3)2 to give stereoselectively (E)-enediynes 5 in good yields. |
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| Keywords: | (E)-1-Arylseleno-substituted 1 3-enyne (E)-enediyne nickel catalysis Sonogashira coupling stereoselective synthesis |
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