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Rapid Access to 1-Benzyl 2-Substituted Piperazines: Application to the Synthesis of 1-Benzyl-2-difluoromethyl-Piperazine |
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| Authors: | Carmela Napolitano Manuela Borriello Francesca Cardullo Daniele Donati Alfredo Paio |
| Affiliation: | 1. Department of Pharmaceutical Sciences , University of Ferrara , Ferrara , Italy;2. GlaxoSmithKline, Neurosciences Centre of Excellence for Drug Discovery, Medicine Research Centre , Verona , Italy |
| Abstract: | A rapid and efficient synthesis of 1-benzyl-2-difluoromethyl-piperazine is herein described. The new pathway has the advantage of avoiding orthogonal protection at the two piperazine nitrogen atoms; therefore it is suitable for access to several 1-benzyl 2-substituted piperazines starting from the simple commercially available N,N′-dibenzylethylendiamine. |
| Keywords: | Chemoselective deprotection piperazines privileged structures |