Synthesis of 8-Aroyl-9-hydroxy-7,9,11-triaryl-3-oxo(or thioxo)-2,4-diazaspiro[5.5]undecane-1,5-diones |
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| Authors: | S Mosaddeq Ahmed Syeda Asghari Ahmed U K R Romman Tazin Sultana M Mahmun Hossain |
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| Institution: | 1. Department of Chemistry , University of Dhaka , Dhaka , Bangladesh;2. Department of Chemistry , University of Wisconsin–Milwaukee , Milwaukee , Wisconsin , USA |
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| Abstract: | A number of 8-aroyl-9-hydroxy-7,9,11-triaryl-3-oxo(or thioxo)-2,4-diazaspiro5.5]undecane-1,5-diones 3a–g were synthesized from the reaction of 1,3-diaryl-2-propen-1-ones 2a–d with barbituric acid 1a and 2-thiobarbituric acid 1b in 50% aqueous ethanol under refluxing conditions without using any catalyst. The structures of the compounds were confirmed by ultraviolet, infrared, 1H and 13C NMR, mass, and elemental analysis. |
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| Keywords: | Barbituric acid chalcones Michael addition spiro compounds 2-thiobarbituric acid |
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