Simple and Efficient Method for Synthesis of Novel 4-Substituted 1-Acylthiosemicarbazides via One-Pot Multicomponent Reactions |
| |
| Authors: | Naser Foroughifar Akbar Mobinikhaledi Hassan Moghanian |
| |
| Affiliation: | 1. Department of Chemistry , Faculty of Sciences, Arak University , Arak, Iran n_foroughifar@yahoo.com;3. Department of Chemistry , Faculty of Sciences, Arak University , Arak, Iran |
| |
| Abstract: | A new one-pot, multicomponent condensation reaction of aldehydes, 2-naphthol, and 1-acylthiosemicarbazides is described as an efficient method for the synthesis of novel 4-substituted 1-acylthiosemicarbazides in the presence of p-toluenesulfonic acid (p-TSA) as a catalyst under two conditions: organic solvent and solvent-free media. The present procedure offers several advantages, such as good yields, low cost, and very easy workup. |
| |
| Keywords: | Acylthiosemicarbazide condensation naphthol one-pot reaction solvent-free |
|
|
