Efficient One-Pot Synthesis of Substituted Pyrido[2,3-d]pyrimidines from Vinamidinium and Chloropropeniminium Salts |
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| Authors: | Mohamed Adnen Hadj Ayed Thouraya Gmiza Jamel Eddine Khiari |
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| Institution: | 1. University of Monastir, Laboratoire de Synthèse Organique Asymétrique et Catalyse Homogène (01UR1201), Faculté des Sciences de Monastir , Tunisia;2. University of Carthage, Laboratoire de Chimie Organique et Analytique, Institut Supérieur de l'Education et de la Formation Continue, Bardo , Tunisia |
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| Abstract: | A novel and efficient one-pot preparation of 6-substituted pyrido-2,3-d]pyrimidines by cyclocondensation of 6-amino-1,3-dimethyluracil with symmetrical vinamidinium salts under basic conditions has been developed. Regioselectivity was observed with an unsymmetrical chloropropeniminium salt. |
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| Keywords: | 6-Amino-uracil chloropropeniminium salts cyclocondensation trisubstituted pyrido[2 3-d]pyrimidines vinamidinium salts |
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