Recyclable Siloxy Serine Organocatalyst for the Direct Asymmetric Mannich Reactions in Ionic Liquids

A recyclable siloxy-L-serine organocatalyst has been developed to catalyze the asymmetric direct three-component Mannich reactions in ionic liquid hmim[PF₆], furnishing the β-amino carbonyl scaffold in high enantio- and diastereoselectivities. The direct Mannich reaction between a selection of aromatic aldehydes and ketones resulted in good yields and high enantioselectivities.

Keywords: β-Amino carbonyl compounds, asymmetric Mannich, enantiomeric excess, organocatalyst, serine

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ACKNOWLEDGMENT

We thank the National Institute of Education (RP05/06 TYC), Nanyang Technological University, for their generous financial support.