Synthesis and Evaluation of Polyfunctionally Substituted Heterocyclic Compounds Derived from 2-Cyano-N-(5-pentadecyl-1,3,4-thiadiazol-2-yl)acetamide |
| |
| Authors: | Refat El-Sayed Amani Shaldom Layla Al Mazrouee |
| |
| Institution: | 1. Chemistry Department, College of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia;2. Chemistry Department, Faculty of Science, Benha University, Benha, Egyptref_at@hotmail.com |
| |
| Abstract: | Reaction of 5-pentadecyl-1,3,4-thiadiazol-2-amine 2 with ethyl cyanoacetate gave 2-cyano-N-(5-pentadecyl-1,3,4-thiadiazol-2-yl)acetamide 3, which was used to synthesize different heterocyclic derivatives with coumarin, pyrazole, thiazole, pyridine, pyrimidine, and thiophene rings. Propoxylation of these compounds by using 5 mol of propylene oxide produced nonionic surface active agents. Antimicrobial and surface activities were evaluated. |
| |
| Keywords: | Antimicrobial activity surface activity synthesis |
|
|
