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Synthesis of New Pyrazolo[1.5.4-de]quinoxalines |
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| Authors: | Mohammed Boutayeb Soufiane El Imadi El Mokhtar Essassi Nour-Eddine Es-Safi Lahcen El Ammari |
| Institution: | 1. Laboratoire de Chimie Organique Hétérocyclique, Faculté des Sciences, Université Mohammed V , Rabat, Morocco;2. Laboratoire de Chimie du Solide Appliquée, Faculté des Sciences, Université Mohammed V , Rabat, Morocco |
| Abstract: | New pyrazolo1.5.4-de]quinoxaline derivatives were prepared by the action of 7-aminoindazole 1 on diethyl and dimethyl acetylene dicarboxylates. The structures of the obtained compounds and the direction of cyclization were investigated through a crystallographic study of compound 2. Further alkylation, hydrogenation, and bromination were also explored. The action of potassium thiocyanate on the obtained halo product led to a tetracyclic compound of 1.3-thiazolo3.4-a]pyrazolo1.5.4-de]quinoxaline series. |
| Keywords: | 7-Amino indazole diethyl acetylene dicarboxylate heterocyclization hydrogenation pyrazolo[1 5 4-de]quinoxaline |