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Palladium-Catalyzed Coupling Reaction of Iodouracil Having Acetamidine Moiety with Olefins |
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| Authors: | Young Hae Roh Jong Woo Bae Gil Soo Nam Joong Hyup Kim Sung Hoon Kim Cheol Min Yoon |
| Affiliation: | 1. Biochemicals Research Center, Korea Institute of Science and Technology , P. O. Box 131, Cheongryang, Seoul, Korea;2. Department of Life Science &3. Biotechnology, Graduate school of Biotechnology , Korea University , Sungbookgu Anamdong 5 ga 126--16, Seoul, Korea |
| Abstract: | The reaction of 6-[1-Aza-2-(dimethylamino)prop-l-enyl]-5-iodo-1,3-dimethyluracil (3) with various olefins in the presence of a catalytic amount of Pd(OAc)2 and 1.5 equiv. of K2CO3 in DMF at 120 °C gave the pyrido[2,3-d]pyrimidine derivatives (5a-b and 7a-d) in moderate to high yield. |
| Keywords: | Alkylation cesium carbonate macrolides pyridyl imidazole regioselective |