Highly Efficient System for Reduction of Carboxylic Acids and Their Derivatives to Alcohols by HfCl4/KBH4 |
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| Authors: | Jianghua Zhang Chengyi Zhang Jianfei Ma Defeng Zhao |
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| Institution: | State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian, China |
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| Abstract: | HfCl4/KBH4 was found to be a facile, efficient, convenient, and chemoselective system for the reduction of carboxylic acids and their derivatives to the corresponding alcohols under mild conditions. HfCl4/NaBH4 was also utilized to reduce the same carboxylic acids and their derivatives, and it was found that the reducing ability of HfCl4/NaBH4 was similar to that of HfCl4/KBH4. The action of HfCl4/KBH4 on other types of substrates, such as benzyl chloride, peracid, epoxide, ketone, amide, imine, pyridine-N-oxide, and nitrile, was investigated, too. In addition, some competitive reductions of styrene oxide in the presence of carboxylic acid, carboxylic ester, nitrile, and amide were achieved. |
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| Keywords: | Alcohols carboxylic acid derivatives carboxylic acids HfCl4/KBH4 reduction |
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