Microwave-Promoted Facile and Rapid Synthesis Procedure for the Efficient Synthesis of 5,5-Disubstituted Hydantoins |
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| Authors: | Javad Safari Soheila Gandomi-Ravandi Leila Javadian |
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| Affiliation: | 1. Laboratory of Organic Chemistry Research, Department of Chemistry, College of Chemistry, University of Kashan , Kashan , Iran Safari@kashanu.ac.ir;3. Laboratory of Organic Chemistry Research, Department of Chemistry, College of Chemistry, University of Kashan , Kashan , Iran |
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| Abstract: | A fast, general, environmentally friendly, and facile method for preparation of 5, 5-disubstituted hydantoins from the reaction between ketone (or aldehyde) derivatives with KCN and ammonium carbonate under microwave irradiation is presented. The microwaves remarkably accelerated this reaction, the reaction times decreased dramatically, the reaction conditions were milder, and the yields were also greater. Also a comparative study of microwave versus classical conditions has been done. All the products were characterized by infrared, NMR, and CHN analysis, and their melting points are identical to those of the known compounds reported in the literature. This method might be useful in the future for the preparation of similar derivatives. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resources: Full experimental and spectral details.] |
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| Keywords: | Bucherer–Bergs reaction hydantoin microwave irradiation multi-component reaction |
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