Improved Synthesis of Monoprotected 5- and 6-Amino-2-azanorbornanes |
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| Authors: | Oleksandr P. Dacenko Olga V. Manoylenko Pavel K. Mykhailiuk Dmitriy M. Volochnyuk Oleg V. Shishkin |
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| Affiliation: | 1. Enamine Ltd. , Kyiv , Ukraine;2. Enamine Ltd. , Kyiv , Ukraine;3. Department of Chemistry , Kyiv National Taras Shevchenko University , Kyiv , Ukraine;4. STC Institute for Single Crystals, National Academy of Science of Ukraine , Kharkiv , Ukraine |
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| Abstract: | An improved synthesis of Boc-monoprotected 5- and 6-amino-2-azanorbornanes is reported. The synthetic scheme consists of five steps and allows multigram quantities of the title compounds to be obtained. The regio- and stereochemistries of the products are established by two-dimensional NMR experiments.  Additional information ACKNOWLEDGMENT The authors are thankful to Mr. Vitaliy Polovinko for the 2D NMR experiments. |
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| Keywords: | Bicyclic compounds cycloadditions diamines molecular rigidity peptidomimetics |
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