Ligand-supported palladium-catalyzed cross-coupling reactions of (hetero) aryl chlorides |
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| Authors: | Efeturi Abraham Onoabedje Uchechukwu Chris Okoro |
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| Institution: | 1. Department of Pure &2. Industrial Chemistry, University of Nigeria, Nsukka, Enugu State, Nigeriaefeturi.onoabedje@unn.edu.ng;4. Industrial Chemistry, University of Nigeria, Nsukka, Enugu State, Nigeria |
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| Abstract: | The introduction of electron rich and sterically hindered ligands has made otherwise inert aryl chlorides and hetero aryl chlorides viable coupling partners in palladium-catalyzed Suzuki-Miyaura, Sonogashira, Stille and other types of cross-coupling reactions. This review gives highlights of cross-coupling of aryl chlorides employing in situ generated palladium catalytic systems. |
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| Keywords: | Aryl chloride Buchwald–Hartwig reaction cross-coupling Sonogashira reaction Stille reaction Suzuki–Miyuara reaction |
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