Solvent-Free One-Pot Synthesis of Sulfonephthaleins from Saccharin and Phenols |
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| Authors: | V H Tillu D K Dumbre H B Borate R D Wakharkar |
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| Institution: | 1. Organic Chemistry Division, National Chemical Laboratory , Pune , India;2. Chemical Engineering and Process Development Division, National Chemical Laboratory , Pune , India |
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| Abstract: | Sulfonephthaleins can be synthesized in a single pot from saccharin and phenol via the in situ formation of 2-sulfobenzoic anhydride, followed by its reaction with phenol using H2SO4 as the condensing agent, in the absence of any solvent. This solvent-free synthesis is more economical and environmentally benign. |
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| Keywords: | H2SO4 phenols saccharin sulfonephthalein |
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