Direct 2-Arylation of Thiophene Using Low Loading of a Phosphine-Free Palladium Catalyst |
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Authors: | Souhila Bensaid Julien Roger Kassem Beydoun David Roy |
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Affiliation: | Institut Sciences Chimiques de Rennes, CNRS-Université de Rennes “Catalyse et Organometalliques,” , Rennes , France |
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Abstract: | The direct coupling of aryl halides with thiophene would be a considerable advantage for sustainable development because of only HBr associated with a base as by-product is formed and the number of steps to prepare these compounds is less than in more classical coupling reactions. We observed that through the use of only 0.2 mol% Pd(OAc)2 as the catalyst, a range of aryl bromides undergoes coupling via a C-H bond activation/functionalization reaction with thiophene to give 2-arylated thiophenes in good yields. In most cases, only traces of polyarylated thiophenes were detected when a large excess of thiophene was employed. This air-stable catalyst can be used with a wide variety of aryl bromides. |
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Keywords: | Aryl bromides catalysis C-H activation palladium thiophene |
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