Synthesis of Aryl Ketones by Cross-Coupling Reaction of Arylboronic Acids with Carboxylic Anhydrides in Aqueous Phase |
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Authors: | Bing-Wei Xin |
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Affiliation: | 1. Department of Chemistry , Dezhou University , Dezhou, China bingweixin2@163.com |
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Abstract: | A highly efficient aqueous system of PdCl2-catalyzed cross-coupling reaction of arylboronic acid with carboxylic anhydride (Suzuki-type reaction) without the use of phosphine ligands was developed. The reactions went smoothly in acetone/H2O phase to give good yields of aryl ketones in short reaction times (1–3 h) at room temperature in air and were unaffected by the presence of electron-releasing and electron-withdrawing substituents in both the arylboronic acids and carboxylic anhydrides. |
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Keywords: | acetone aryl ketones boronic acids carboxylic anhydrides palladium catalysis |
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