Sequential 1,3-Dipolar Cycloadditions in the Synthesis of Novel Tri-spiro Cyclohexanones and Piperidin-4-ones |
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| Authors: | Raju Ranjith Kumar Balaganesan Loganayaki |
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| Affiliation: | Department of Organic Chemistry , School of Chemistry, Madurai Kamaraj University , Madurai, India |
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| Abstract: | The sequential 1,3-dipolar cycloadditions of azomethine ylide and nitrile oxide to a series of 2,6-bis[(E)-arylmethylidene]cyclohexanones and 1-methyl-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones afforded novel tri-spiro heterocycles comprising isoxazoline, pyrrolidine and acenaphthylen-1(2H)-one rings in good yields and stereoselectivity. |
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| Keywords: | Azomethine ylide 1,3-dipolar cycloaddition isoxazolines nitrile oxide pyrrolidines |
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