Efficient One-Pot Synthesis of 4-Aroyl-2-pyrones: Nucleophilic Addition of Active Methylene Groups to 1,2-Diaroylacetylenes |
| |
| Authors: | Ravi Shankar Harsha Shukla Uma Sharan Singh Vinay Thakur |
| |
| Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute , Lucknow , India |
| |
| Abstract: | An efficient synthesis of 3,6-disubstituted-4-aroyl-2-pyrones in a single-step reaction through Michael addition of 1,2-diaroylacetylenes with active methylene compounds in the presence of NaH in dimethylsulfoxide at room temperature is reported. The structures have been confirmed by spectral data analyses.  Additional information ACKNOWLEDGMENTS Ravi Shankar is thankful to the Council of Scientific and Industrial Research for a senior fellowship; Uma Sharan Singh and Harsha Shukla are grateful to the Ministry of Health and Family Welfare for financial assistance; and all authors thank Sophisticated Analytical Instrument Facility (SAIF) for spectroscopic analyses of the compounds. |
| |
| Keywords: | 4-Aroyl-2-pyrones 1 2-diaroylacetylenes Michael addition |
|
|
