A Simple Strategy for the Preparation of 6-Substituted 3H-Benzoxazol-2-ones and 3H-Benzothiazol-2-ones |
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| Authors: | Russell J DeOrazio Jun-Ho Maeng Brian A Sherer Ian L Scott Sham S Nikam |
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| Institution: | 1. AMRI , Albany , New York , USA;2. Pfizer Inc. , Ann Arbor , Michigan , USA |
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| Abstract: | The double metallation of 6-bromo-3H-benzothiazol-2-one and 6-bromo-3H-benzoxazol-2-one with methyl magnesium bromide and alkyllithium bases is described. Alkylation with a variety of electrophiles occurs at the 6-position of the heterocycles in good yields.  |
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| Keywords: | Benzothiazolidinone benzoxazolidinone metallation |
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