AlCl3 as an Efficient Catalyst Toward the Synthesis of 1,6-Dihydropyrazine-2,3-dicarbonitrile Derivatives

Aluminium chloride has been shown to be an efficient catalyst for the multicomponent reactions of diaminomaleonitrile (DAMN), ketones or aldehydes, and isocyanides for the synthesis of 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives using comparative study with various catalysts. Unprecedented use of aromatic and aliphatic aldehydes in this multicomponent reaction (MCR) was demonstrated.

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