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New Protocol for Masking and Unmasking Vicinal Hydroxyl and Formyl Groups in 6-Hydroxyarene-1,3-dicarboxaldehydes |
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| Authors: | Koneni V. Sashidhara Jammikuntla N. Rosaiah Abdhesh Kumar |
| Affiliation: | 1. Medicinal and Process Chemistry Division , Central Drug Research Institute , Lucknow, India sashidhar123@gmail.com;3. Medicinal and Process Chemistry Division , Central Drug Research Institute , Lucknow, India |
| Abstract: | A simple and efficient protocol is revealed for the masking and unmasking of an α-hydroxyl benzaldedyde group in aromatic dialdehydes by forming keto-enamine Schiff bases and subsequent unmasking using NaN3/DMF. |
| Keywords: | Enamine 2-hydroxy benzaldehydes masking NMR spectroscopy regioselectivity Schiff bases unmasking |