One-Pot Efficient Synthesis of Fully Substituted 1,3,4-Oxadiazole Derivatives from (N-Isocyanimino)triphenylphosphorane,Carboxylic Acids,and Aromatic Bis-Aldehydes |
| |
| Authors: | Ali Ramazani Yavar Ahmadi Amir Mahyari |
| |
| Institution: | 1. Chemistry Department , Zanjan University , Zanjan , Iran aliramazani@gmail.com;3. Young Researchers Club , Islamic Azad University, Zanjan Branch , Zanjan , Iran;4. Chemistry Department , Zanjan University , Zanjan , Iran |
| |
| Abstract: | Reactions of (N-isocyanimino)triphenylphosphorane with aromatic bis-aldehydes (isophthalaldehyde and terphthalaldehyde) in the presence of aromatic (or heteroaromatic) carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in good yields. The reaction proceeds smoothly and cleanly under mild conditions, and no side reactions were observed.  Additional information ACKNOWLEDGMENTS This research was supported by Zanjan University and the Iranian National Science Foundation (INSF). |
| |
| Keywords: | Aromatic carboxylic acid aza-Wittig reaction heteroaromatic carboxylic acid (N-isocyanimino)triphenylphosphorane 1 3 4-oxadiazole |
|
|
