Methanesulfonic Acid/SiO2 as an Efficient Combination for the Synthesis of 2-Substituted Aromatic and Aliphatic Benzothiazoles from Carboxylic Acids |
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| Authors: | Hashem Sharghi Omid Asemani |
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| Affiliation: | 1. Department of Chemistry , Shiraz University , Shiraz, Iran shashem@chem.susc.ac.ir;3. Department of Medicinal Chemistry, Faculty of Pharmacy , Shiraz University of Medical Sciences , Shiraz, Iran;4. Medicinal and Natural Products Chemistry , Research Center, Shiraz University of Medical Sciences , Shiraz, Iran |
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| Abstract: | Methanesulfonic acid/SiO2 (1 mL/0.3 g) was found to be as an expeditious mixture in the synthesis of 2-substituted aromatic and aliphatic benzothiazoles at 140 °C using carboxylic acids. After a simple workup, benzothiazoles were obtained in good yields. Simplicity, use of widely available and diverse carboxylic acids, and easy handling of the reaction conditions are among the benefits of the method. |
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| Keywords: | 2-Alkylbenzothiazoles 2-arylbenzothiazoles methanesulfonic acid silica gel |
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