Parallel Synthesis of Novel 3-Substituted 1-Ethyl-6-methylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione Analogs |
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Authors: | Yongsheng Chen Jack R. Barber Shi Chung Ng Yuefen Zhou |
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Affiliation: | 1. CytRx Corporation , San Diego, California, USA ychen@cytrx.com;3. CytRx Corporation , San Diego, California, USA |
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Abstract: | A library of novel 1H-pyrimido[4,5-c]pyridazine-5,7-dione analogs was prepared in a parallel fashion via the cyclization of 6-(1-ethylhydrazinyl)-3-methylpyrimidine-2,4(1H,3H)-dione (4) with α-bromoketones and was then isolated by a two-step purification method with >90% purity. Both the library synthesis and purification method proved suitable for analogs with a high diversity of substitution at the 3-position including various alkyl, aryl, and heteroaryl groups. |
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Keywords: | Cyclization 6-(1-ethylhydrazinyl)-3-methylpyrimidine-2,4(1H,3H)-dione parallel synthesis 1H-pyrimido[4,5-c]pyridazine-5,7-dione analogs |
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