Synthesis of Derivatives of Chlorin P6 Trimethyl Ester |
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| Authors: | Guang-Fan Han Wei Dai Wen-Tao Zhang Zheng Xing Yu-Yuan Zhao |
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| Institution: | 1. School of Material Science and Engineering, Jiangsu University of Science and Technology , Zhenjiang, Jiangsu, China gf552002@yahoo.com.cn;3. School of Material Science and Engineering, Jiangsu University of Science and Technology , Zhenjiang, Jiangsu, China |
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| Abstract: | The Vilsmeier reaction of nickel(II) chlorin P6 trimethyl ester with 3-dimethyl-aminoacrolein yielded nickel(II) chlorin P6 20-(2-formylvinyl) trimethyl ester and nickel(II) chlorin P6 3-(1-hydroxyethyl)-3-devinyl-20-(2-formylvinyl) trimethyl ester. Also, the outgrowths of nickel(II) chlorin P6 20-(2-formyl) trimethyl ester and nickel(II) chlorin P6 3-(2-formylvinyl)-3-devinyl-20-(2-formyl) trimethyl ester were obtained by Vilsmeier reaction with dimethylformamide. By treating the derivatives of nickel(II) 20-(2-formyl)-chlorin and nickel(II) 3-(2-formylvinyl)-20-(2-formyl)-chlorin with trifluoracetic acid, the removal of the central nickel(II) ion was accomplished. The derivatives of 20-(2-formyl)-chlorin and 3-(2-formylvinyl)-20-(2-formyl)-chlorin demonstrated considerable bathochromic shift of the major absorption band in the red region of the optical spectrum. |
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| Keywords: | Chlorin P6 trimethyl ester formyl- formylvinyl- photodynamic therapy Vilsmeier reaction |
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