A New Approach to the Efficient Method for the Asymmetric Synthesis of (S)-O-, M-, P-Fluorophenylalanines and Their 2-Methyl-substituted Analogs |
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| Authors: | Ashot S Saghiyan Satenik G Petrosyan Luiza L Manasyan Slavik A Dadayan Arpine V Geolchanyan Henry A Panosyan |
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| Institution: | 1. Chemistry Department , Yerevan State University , Yerevan, Armeniasaghiyan@netsys.am;3. Chemistry Department , Yerevan State University , Yerevan, Armenia;4. Molecular Structure Research Center of National Academic of Sciences , Yerevan, Armenia |
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| Abstract: |  Abstract The reactions of asymmetric C-alkylation of glycine and alanine in NiII complexes of their Schiff's bases with modified chiral auxiliaries (S)-2-N-(N′-2-chlorobenzylprolyl)amino]benzophenone and (S)-2-N-N′-(3,4-dimethylbenzylprolyl)amino]benzophenone by fluorine-substituted benzyl halogenides have been studied. As a result, a highly stereoselective and relatively rapid method for the asymmetric synthesis of (S)-o-, m-, p-fluorophenylalanines and their 2-methyl substituted analogs has been developed. |
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| Keywords: | Asymmetric synthesis c-alkylation chiral NiII complex fluorophenylalanine |
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