Optimization of the Microwave-Assisted Ortho Ester Claisen Rearrangement: Application to Monoterpenols |
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| Authors: | Florence Mehl Carine Franklin Emile M Gaydou |
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| Institution: | 1. Paul Cezanne University, Faculty of Sciences and Technology of Saint-Jér?me, Molecular Science Institute of Marseille, Phytochemistry Group , Marseille, France;2. Technological University Institute of Marseille, Chemistry Department , Marseille, France |
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| Abstract: | Two monoterpenols, perillyl alcohol and nerol, have been converted into their γ,δ-unsaturated ester derivatives following a modified process of microwave-assisted ortho ester Claisen rearrangement. The yields obtained (>90%) are better than those previously obtained. The optimized process needs less reaction time (5 min), smaller amount of reagent, and no solvent. |
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| Keywords: | Focused microwave Johnson–Claisen monoterpenol ortho ester rearrangement |
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