A Novel and Efficient Reaction of Imidazolidin-2-one and N-Acylbenzotriazoles: A Facile Synthesis of 1-Acylimidazolidin-2-one |
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Authors: | Jianjun Li Yan Sun Zhiwei Chen |
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Affiliation: | Key Laboratory of Pharmaceutical Engineering of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology , Hangzhou, P.R. China |
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Abstract: | Acylation of imidazolidin-2-one with readily available N-acylbenzotriazoles, in the presence of K2CO3, produced 1-acylimidazolidin-2-ones and N,N′-diacyl-imidazolidin-2-one in moderate to good yields. The utilization of N-acylbenzotriazoles which make the reaction simple and mild, may be especially advantageous when the corresponding acid chlorides are not stable or not easily prepared. It's also an example of the reaction of N-acylbenzotriazoles and amide. |
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Keywords: | Acylation N-acylbenzotriazoles 1-acylimidazolidin-2-one amides |
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