Intramolecular Heck Reaction on Bromobenzyloxy-Substituted Chromenes: Formation of Chelated Ketones |
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| Authors: | Amarendra Patra Tanusri Mahapatra |
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| Affiliation: | 1. Department of Chemistry , University of Calcutta, University College of Science and Technology , Calcutta , India amarendra.patra@gmail.com;3. Department of Chemistry , University of Calcutta, University College of Science and Technology , Calcutta , India |
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| Abstract: | Heck reaction on 2-bromobenzyloxy-substituted 4H-chromene derivatives using Pd(OAc)2 in Aliquat 336 and N,N-dimethylformamide mixture leads to intramolecular heteroannulation along with hydrolysis, affording chelated 6H-benzo[c]chromen-2-yl ketones. The method offers Pd(0)-catalysis and regioselectivity in product formation. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. |
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| Keywords: | Aliquat 336 chelated ketones intramolecular Heck cyclization Pd(0) catalysis |
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