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Preparation of Primary Thioamides From Nitriles Using Sodium Hydrogen Sulfide and Diethylamine Hydrochloride |
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| Authors: | Mark L Boys Victoria L Downs |
| Institution: | 1. Department of Chemistry , Pfizer Global R&2. D , Ann Arbor, Michigan, USA mark.l.boys@pfizer.com;4. D , Ann Arbor, Michigan, USA |
| Abstract: | Primary thioamides are prepared in moderate to excellent yields by treating nitriles with sodium hydrogen sulfide and diethylamine hydrochloride in an appropriate solvent with mild heating. |
| Keywords: | Diethylamine hydrochloride nitrile sodium hydrogen sulfide thioamide |