Ecofriendly and Efficient One-Pot Procedure for the Synthesis of Quinazoline Derivatives Catalyzed by an Acidic Ionic Liquid Under Aerobic Oxidation Conditions |
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| Authors: | Minoo Dabiri Peyman Salehi Mahboobeh Bahramnejad |
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| Affiliation: | 1. Faculty of Science, Department of Chemistry , Shahid Beheshti University , Tehran, Iran m-dabiri@sbu.ac.ir;3. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute , Shahid Beheshti University , Tehran, Iran;4. Faculty of Science, Department of Chemistry , Shahid Beheshti University , Tehran, Iran |
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| Abstract: | A three-component condensation reaction between 2-aminobenzophenone derivatives, formaldehyde or aromatic aldehydes, and ammonium acetate efficiently provides substituted quinazolines in a one-pot reaction in the presence of Brönsted acidic ionic liquid, 1-methylimidazolium triflouroacetate ([Hmim]TFA), in conjunction with aerobic oxidation. The ionic liquid was separated from the reaction mixture by simple extraction and was recycled three times without considerable loss in activity. |
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| Keywords: | Aerobic oxidation catalysis heterocycles multicomponent quinazolines |
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