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Synthesis and Evaluation of Novel Compounds as Potent Dipeptidyl Peptidase IV Inhibitors |
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| Authors: | Liutang Wang Bin Zhang Jianxin Ji Bogang Li Jufang Yan Weiyu Zhang |
| Affiliation: | 1. West China School of Pharmacy, Sichuan University , Chengdu , China;2. Department of Research and Development , Di'ao Co. Ltd , Chengdu , China;3. Department of Research and Development , Di'ao Co. Ltd , Chengdu , China |
| Abstract: | A series of new 2-cyanopyrrolidine derivatives with constrained imidazolidin ring were synthesized, Their structures were confirmed by 1H NMR spectroscopy and/or mass spectrometry, and their activities were evaluated in vitro. They were proven to possess submicromolar inhibitory activities against dipeptidyl peptidase IV. |
| Keywords: | Antidiabetic agent 2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors imidazolidin derivatives |