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Synthesis of All Enantiomerically Pure Diastereomers of Aprepitant |
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| Authors: | Srinivas Gangula Chandrashekhar R Elati Satish Varma Mudunuru Anitha Nardela Ashok Dongamanti Apurba Bhattacharya |
| Institution: | 1. Innovation Plaza, Dr. Reddy's Laboratories Ltd. , Bachupally, Qutubullapur, India;2. Department of Chemistry , Osmania University , Hyderabad, India |
| Abstract: | Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and x-ray crystallographic analysis were achieved. |
| Keywords: | ICH spectroscopy stereoisomers synthesis X-ray crystallography |