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A Short and Efficient Stereoselective Synthesis of the Potent 5-Lipoxygenase Inhibitor CMI-977 |
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| Authors: | Darren J Dixon Steven V Ley Dominic J Reynolds Mukund S Chorghade |
| Institution: | 1. Department of Chemistry , University of Cambridge , Lensfield Road, Cambridge , CB2 1EW , UK;2. LeukoSite Inc. , 215 First Street, Cambridge , Massachusetts , 02142 , USA |
| Abstract: | A short and efficient synthesis of the potent 5-lipoxygenase inhibitor CMI-977 is described using as the key step a stereoselective anomeric oxygen to carbon rearrangement of an alkynyl stannane tetrahydrofuranyl ether derivative mediated by boron trifluoride etherate. |
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