Palladium-Catalyzed N-Arylation of 3-Functionalized 2-Amino-4,5-dimethylpyrroles |
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| Authors: | Carlos P Griswold Nisaraporn Suthiwangcharoen Steven M Pochini |
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| Institution: | Department of Chemistry and Physics , Augusta State University , Augusta , Georgia , USA |
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| Abstract: | A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladium-catalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.  Additional information ACKNOWLEDGMENTS We thank our department and the Pamplin College of Arts and Sciences for funding of this research. |
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| Keywords: | 2-Aminopyrrole DPEphos N-arylation palladium-catalyzed pyrrolo[2 3-d]pyrido[1 2-a]pyrimidine xantphos |
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