In Situ Generation of Formaldehyde and Triphenylphosphine from (Hydroxymethyl)triphenylphosphonium and Its Application in Wittig Olefination |
| |
| Authors: | Wenhua Huang Jie Xu |
| |
| Institution: | 1. Department of Chemistry, Tianjin University, Tianjin, Chinahuangwh@tju.edu.cn;3. Department of Chemistry, Tianjin University, Tianjin, China |
| |
| Abstract: | The reaction of (hydroxymethyl)triphenylphosphonium with benzylic or allylic halide under basic conditions at room temperature affords terminal alkenes in 61–89% yields. In this reaction, both formaldehyde and triphenylphosphine are in situ generated from (hydroxymethyl)triphenylphosphonium and further undergo Wittig olefination with benzylic or allylic halide. |
| |
| Keywords: | Formaldehyde (hydroxymethyl)triphenylphosphonium triphenylphosphine terminal alkene Wittig olefination |
|
|
