Practical Synthesis of Functionalized 2‐Thioxoimidazolidine Derivatives |
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| Authors: | Samia Bouzroura Lamouri Hammal Fadila Balegroune Malika Hamadène Sophie Poulain |
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| Institution: | 1. Laboratory of Applied organic Chemistry , Houari Boumediene University of Sciences and Technology , Algiers, Algeria;2. Laboratory of Cristallography , USTHB , Algiers, Algeria;3. Sophia Antipolis University , UMR 6001, Nice, France |
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| Abstract: | High‐yielding syntheses of an unpublished series of 2‐thioxo‐imidazolidin‐4‐ones 6 bearing an N‐ethoxycarbonyl and amidyl moieties an N1 and C5, respectively, are reported. These derivatives were obtained by intramolecular cyclization of 3‐ethylhydrazinoacetate 3,4‐dihydro maleimides 4 in the presence of ethyl or phenylisothiocyanate 2 under neutral conditions. |
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| Keywords: | arylisothiocyanates imidazolidin‐2‐thione maléimides thioxoimidazolidinones |
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