KF/Al2O3 as a Highly Efficient,Green, Heterogeneous,and Reusable Catalytic System for the Solvent-Free Synthesis of Carboacyclic Nucleosides via Michael Addition Reaction |
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| Authors: | Abdolkarim Zare Mohammad Hassan Beyzavi Ahmad Reza Moosavi Zare Ali Khalafi-Nezhad Fatemeh Asadi |
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| Institution: | 1. Department of Chemistry , College of Sciences, Payame Noor University (PNU) , Bushehr, Iran abdolkarimzare@yahoo.com;3. Department of Chemistry , College of Sciences, Shiraz University , Shiraz, Iran;4. Department of Chemistry , College of Sciences, Payame Noor University (PNU) , Bushehr, Iran |
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| Abstract: | KF/Al2O3 acts as an efficient catalytic system for the synthesis of carboacyclic nucleosides via Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters under solvent-free and microwave conditions. Using this method, the title compounds are produced in good to excellent yields and short reaction times. |
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| Keywords: | Carboacyclic nucleoside KF/Al2O3 Michael addition microwave nucleobase solvent-free |
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