The synthesis of precursor of FP- (+) DTBZ |
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| Authors: | Caijiao Wu Hui Li Feiyang Sun Changshun Bao |
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| Affiliation: | Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, No.103 Wenhua Road, Shenhe District, Shenyang, 110016, P. R. of China |
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| Abstract: | A synthetic route to the precursor of FP- (+) DTBZ was disclosed, in which 3-hydroxy-4-methoxybenzaldehyde was employed as a starting material. In the method, the benzyl-protecting protocol and the in-situ Diels-Alder reaction made the procedure more practical because of the mild conditions for selectively deprotection and the accelerated reaction process. |
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| Keywords: | Positron Emission Computed Tomography VMAT2 imaging agents precursor of FP- (+) DTBZ synthesis |
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