Facile and One-Pot Synthesis of 1,2-Dihydroquinazolin-4(3H)-ones via Tandem Intramolecular Pinner/Dimroth Rearrangement |
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| Authors: | Jian-Hong Tang Da-Xin Shi Li-Jun Zhang Qi Zhang |
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| Institution: | 1. School of Chemical Engineering and Environment , Beijing Institute of Technology , Beijing, China;2. School of Chemistry and Chemical Engineering , Tianjin University of Technology , Tianjin, China |
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| Abstract: | An efficient synthetic method for the preparation of quinazolin-4-one derivatives was designed. The facile condensation of aromatic o-aminonitriles with aromatic aldehydes catalyzed by Lewis acid give 1,2-dihydroquinazolin-4(3H)-ones in moderate to good yields under refluxing dimethylformamide. |
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| Keywords: | Aromatic aldehyde aromatic o-aminonitrile catalyst cyclocondensation one-pot synthesis |
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